This is most likely not a hematolymphoid process but instead a "small round blue cell tumor", something along the lines of Ewings sarcoma or neuroblastoma. Or even a small cell carcinoma (lung primary) or melanoma if this patient is an adult. CD56+/CD45- is the expected phenotype, and we often see CD15 in this setting. Additional clinical history should be helpful in this instance. Jeannine Holden, M.D. Director, Hematopathology Emory University School of Medicine. Quoting "G.J. Vrielink" <gj.vrielink@freeler.nl>: > I have a question about a patient who has in his bone marrow blast > cells with the following immunofenotype: > CD45-, CD15+, CD56+ > CD13-, CD33-, CD34-, CD117-, CD14-, MPO- > CD19-, CD22- > CD3-, CD4-, CD8- > CD138- > Has anyone have an idea what celltype/leukemia this is or which other > monoclonal antibodies i should test > I will thank you for your comments > Thanks a lot > > Gert Jan > > > G.J. Vrielink > St. Lucas Andreas hospital > Clinical labarotory > Amsterdam > > > >Received on Tue May 13 15:18:00 2008
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