Re: K562 Cell Line Surface Markers

Dear Fatema,

K562 cells constitutively express glycophorin-A, but not HLA molecules. They
can be induced to express HLA class 1 molecules by IFN-gamma. However, also
be aware that K562 cell lines obtained from different sources may differ,
for example in HLA class 2 molecule induction by IFN-gamma  (see  Ress SR,
Rousseau J, Eidne K, Ratanjee B, Millar B, Keraan M.  HLA Class II induction
by IFN-gamma in K562 variant cell line:  inhibition by serum lipid.  Human
Immunology 1991;31:57-66).


I don't know if this helps.

Regards,

 Stan


On 12/13/06, Fatema Legrand <fatema.legrand@bn-immunotherapeutics.com>
wrote:
>
>  Hi everyone,
>
> I was wondering if anyone was aware of whether the cell surface markers
> for the myelogenous leukemia cell line K562 have been characterized.
>
> I would greatly appreciate any input you may have.
>
>
>
> Kindest regards,
>
> Fatema Legrand
>
>
>